Faculty Information - KOBAYASHI Kenichi

Top page of Faculty introduction

Present specialized field

Academic background

Business career

Main Subject

Book and thesis

Academic conference presentation

Committee and society

（Last updated : 2024-04-25 22:12:30）

KOBAYASHI Kenichi
Department Notre Dame Seishin University Department of Foods and Human Nutrition, Faculty of Human Life Sciences

Graduate Scool Research Course in Food Science and Nutrition Masater's Courese, Graduate Scool of Human Life Sciences

Graduate Scool Research Course in Comprehensive Human Life Sciences Doctoral Courese, Graduate Scool of Human Life Sciences

Graduate Scool Research Course in Human Living Sciences Masater's Courese, Graduate Scool of Human Life Sciences

Notre Dame Seishin University , Inclusive Education Research Center

Position Professor

■ Present specialized field

Food sciences, Family and consumer sciences, and culture and living, Physiology, Applied molecular and cellular biology, Nutrition science and health science

■ Academic background

1.	2002/04～2005/03	〔Doctorial Course (2nd Semester)〕, Kyoto University, Completed,
2.	2000/04～2002/03	〔Master Course〕, Graduate School, Division of Agriculture, Kyoto University, Completed,
3.	1999/04～2000/03	Research Institute for Food Science, Kyoto University

■ Business career

1.	2024/04～	Notre Dame Seshin University Notre Dame Seshin University Library Director of Notre Dame Seshin University Library
2.	2023/04～	Notre Dame Seishin University Vice-President for Academic Affairs
3.	2023/04～	Notre Dame Seishin University NDSU Institutional Research Center Director
4.	2021/04～2023/03	Notre Dame Seishin University Academic Office Head of Academic Office
5.	2020/04～	Notre Dame Seishin University Inclusive Education Research Center Professor
6.	2011/05～2012/03	The University of Sydney, Australian Centre for Microscopy & Microanalysis Visiting Scholar

■ Book and thesis

1.	2024/04/25	Article	Multiorgan linkage and abnormalities of NAD and tryptophan metabolism in obesity-induced diseases, and creation of functional foods from this perspective Community-based care system 26(5),pp.55-58 (Collaboration)
2.	2024/02/12	Article	Multi-organ association of obesity-Induced diseases and abnormal tryptophan metabolism and creation of functional foods targeting them Community-based care system 26(2),pp.67-70 (Collaboration)
3.	2024/01/05	Article	Chronic organ damage: Understanding fibrosis Open Access Government January 2024. 2024(January),pp.58-59 (Single)
4.	2023/09/01	Article	Elucidation of the organ fibrosis-inducing action of quinolinic acid and search for food ingredients that protect the body from organ fibrosis Impact 2023(3),pp.15-17 (Single)
5.	2023/04/20	Article	Search for naturally occurring compounds that protect "brain" and "kidney" by targeting NMDA receptors. AGRICULTURAL　BIOTECHNOLOGY 7(4),pp.81-85 (Collaboration)
6.	2023/01/20	Article	Multi-organ association of obesity-Induced diseases and abnormal tryptophan metabolism and creation of functional foods targeting them AGRICULTURAL　BIOTECHNOLOGY pp.79-83 (Collaboration)
7.	2022/12/21	Article	Ca2+/Calmodulin induces translocation of membrane-associated TSC2 to the nucleus where it suppresses CYP24A1 expression Bioscience, Biotechnology, and Biochemistry 87(1),pp.45-53 (Collaboration)
8.	2022/09/03	Article	Searching for food ingredients that protect the body from fibrosis AGRICULTURAL　BIOTECHNOLOGY 6(9),pp.57-60 (Collaboration)
9.	2021/09/04	Article	Brown Rice Inhibits Development of Nonalcoholic Fatty Liver Disease in Obese Zucker (fa/fa) Rats by Increasing Lipid Oxidation Via Activation of Retinoic Acid Synthesis Journal of Nutrition 151(9),pp.2705-2713 (Collaboration)
10.	2021/07/20	Article	【re-publish】“Visualization” of the beneficial effect of functional food component using fluorescence labeling strategies AGRICULTURAL　BIOTECHNOLOGY 5(7),pp.89-92 (Single)
11.	2020/12/03	Article	Stability of tuberous sclerosis complex 2 is controlled by methylation at R1457 and R1459 Scientific Reports 10(1),pp.21160 (Collaboration)
12.	2020/11/20	Article	“Visualization” of the beneficial effect of functional food component using fluorescence labeling strategies AGRICULTURAL　BIOTECHNOLOGY pp.47-50 (Single)
13.	2020/09/29	Article	Niclosamide activates the AMP-activated protein kinase complex containing the β2 subunit independently of AMP Bioche Biophys Res Commun S0006-291X(20)31818-0. (Collaboration)
14.	2020/08/01	Article	“Quinolinic Acid Hypothesis” in Chronic Kidney Disease: Elucidation of a Novel Pathological Mechanism for Renal Fibrosis and Creation of Functional Food for Renal Protection KAGAKU TO SEIBUTSU pp.469-476 (Single)
15.	2020/07/20	Article	Possibility of the functional foods for prevention and/or improvement of Chronic Kidney Disease AGRICULTURAL BIOTECHNOLOGY 4(7),pp.61-65 (Single)
16.	2020/06/24	Article	AMP-activated protein kinase regulates alternative pre-mRNA splicing by phosphorylation of SRSF1 Biochem J 477(12),pp.2237-2248 (Collaboration)
17.	2020/01	Article	Activation of peroxisome proliferator-activated receptor gamma/small heterodimer partner pathway prevents high fat diet-induced obesity and hepatic steatosis in Sprague-Dawley rats fed soybean meal. Journal of Nutritional Biochemistry 75,pp.108250 (Collaboration)
18.	2019/09	Book	Student Solutions Mannual for use with BIOCHEMISTRY The Molecular Basis of Life International Sixth Edition (Collaboration)
19.	2019/07	Article	Kinetic analysis of intracellular fluorescence labeling resveratrol in colorectal cancer cell (Caco-2) Digention & Absorption pp.127-130 (Single)
20.	2016	Article	High dietary fat-induced obesity in Wistar rats and type 2 diabetes in nonobese Goto-Kakizaki rats differentially affect retinol binding protein 4 expression and vitamin A metabolism Nutr Res., 36(3),pp.262-270 (Collaboration)
21.	2016	Article	Metabolic abnormalities induced by mitochondrial dysfunction in skeletal muscle of the renal carcinoma Eker (TSC2+/-) rat model Biosci Biotechnol Biochem. 31,pp.1-7 (Collaboration)
22.	2016	Article	The tuberous sclerosis complex model Eker (TSC2+/-) rat exhibits hyperglycemia and hyperketonemia due to decreased glycolysis in the liver. Arch Biochem Biophys. 590,pp.48-55 (Collaboration)
23.	2015	Article	Activation of Nrf2/Keap1 Signaling and Autophagy Induction against Oxidative Stress in Heart in Iron Deficiency Biosci Biotechnol Biochem. 79(8),pp.1366-1368 (Collaboration)
24.	2014/03/25	Article	Nuhitional properties and processing properties (bread making or cookie making) of silk powder and wild silk powder pp.23-31 (Collaboration)
25.	2012/04	Article	Correlative microscopy: providing new understanding in the biomedical and plant sciences Micron 43(5),pp.565-582 (Collaboration)
26.	2012	Article	Imaging fluorescently labeled complexes by means of multidimensional correlative light and transmission electron microscopy: a practical approach Methods Cell Biol, 111,pp.1-20 (Collaboration)
27.	2011	Article	Interaction of activated Rab5 with actin-bundling proteins, L- and T-plastin and its relevance to endocytic functions in mammalian cells Biochem Biophys Res Commun, 407,pp.615-619 (Collaboration)
28.	2009	Article	Application of SYPRO Ruby- and Flamingo-stained polyacrylamide gels to Western blot analysis Analytical Biochemistry 389,pp.171-173 (Collaboration)
29.	2009	Article	Caveolin-1 activates Rab5 and enhances endocytosis through direct interaction Bioche Biophys Res Commun, 378,pp.73-78 (Collaboration)
30.	2009	Article	Change of epigenetic control of cystathionine beta-synthase gene expression through dietary vitamin B12 is not recovered by methionine supplementation, Journal of Nutrigenetics and Nutrigenomics, 2,pp.29-36 (Collaboration)
31.	2009	Article	Faster and more convenient Far-western blotting for identifying Rab5-binding proteins. J. Agric. Sci.., Tokyo　Univ. Agric. 東京農大農学集報, 53,pp.322-326 (Collaboration)
32.	2009	Article	Hamartin-Hsp70 Interaction Is Necessary for Akt-Dependent Tuberin Phosphorylation during Heat Shock, Biosci Biotechnol Biochem, 73,pp.2488-2493 (Collaboration)
33.	2009	Article	Iron deficiency down-regulates the　Akt/TSC1-TSC2/mammalian Target of Rapamycin signaling pathway in rats and in COS-1 cells, Nutrition Research, 29,pp.640-647 (Collaboration)
34.	2009	Article	Physiological Study of Mustard Oil Feeding of Rats 日本食生活学会誌 19,pp.330-334 (Collaboration)
35.	2009	Article	Rab5 affinity chromatography without nonhydrolyzable GTP analogues Zeitchrift fur Naturforschung redaction C, 64,pp.303-306 (Collaboration)
36.	2007	Article	Analysis of Huntington's disease transgenic mice based on "Quinolinate Hypothesis" International Congress Series, 1304,pp.377-379 (Collaboration)
37.	2004	Article	GP2/THP gene family of self-binding, GPI-anchored proteins forms a cluster at chromosome 7F1 region in mouse genome. Biochem. Biophys. Res. Commun., 322,pp.659-64 (Collaboration)
38.	2001	Article	Analysis of C-terminal structure of urinary Tamm-Horsfall protein (THP) reveals that mechanism of the release from the kidney GPI-anchored counterpart is phenylalanine-specific proteolysis. Biochem. Biophys. Res. Commun, 289,pp.1044-1048 (Collaboration)
39.	2001	Article	Conditions for solubilization of Tamm-Horsfall protein/uromodulin in human urine and establishment of a sensitive and accurate enzyme-linked immunosorbent assay (ELISA) method. Arch. Biochem. Biophys. 388,pp.113-120 (Collaboration)
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■ Academic conference presentation

1.	2022/12/24	GAN誘導性NASHモデルマウスでは膵臓のキヌレニン代謝関連遺伝子が軒並み増加する (日本トリプトファン研究会　第41回学術集会)
2.	2022/12/09	Analysis of the effect of coffee polyphenols on the prevention and/or improvement of renal fibrosis (IUNS-ICN 22nd International Congress of Nutrition in Tokyo, Japan)
3.	2022/12/09	Kynurenine metabolism is involved in the link between nonalcoholic fatty liver disease (NASH) and chronic kidney disease (CKD) (IUNS-ICN 22nd International Congress of Nutrition in Tokyo, Japan)
4.	2021/07/04	Identification of the receptors involved in the process of quinolinic acid inducible renal fibrogenesis (75th Annual Meeting of Japan Society of Nutrition and Food Science)
5.	2020/05/16	Searching for brown rice components preventing NAFLD via increasing PGC-1alpha activity
6.	2020/05/16	The Effect of grape polyphenol on renal fibrogenesis in kidney interstitial fibroblasts cells
7.	2020/03/27	Soybean meal prevents high fat diet-induced hepatic steatosis via activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ)/Small heterodimer partner (SHP) pathway in Sprague-Dawley rats
8.	2019/08/21	Antioxidative Activity of three beans ―black soybeans, black matpe and mung beans― (ARAHE The 20th Biennial International Congress 2019)
9.	2018/10/16	Dynamic visualization of anti-colorectal cancer effect of resveratrol using fluorescence labeling strategies (3rd International Conference on Biologically Active Substances, Bioactive Okayama 2018)
10.	2018/10/16	Quinolinic acid phosphoribosyltransferase (QPRT) knockout mouse as a novel noninvasive chronic kidney disease (CKD) animal model and a possible animal model for the search of bioactive compounds with preventive effect in CKD (3rd International Conference on Biologically Active Substances, Bioactive Okayama 2018)
11.	2018/09/19	QUINOLIC ACID, A KYNUREININE PATHWAY METABOLITE, IS THE POSSIBLE TRIGGER MOLECULE OF RENAL FIBROSIS (The 15th International Society for Tryptophan Research (ISTRY) Conference)
12.	2018/05/12	AMPK regulates microtubule formation via MAP1B phosphorylation.
13.	2018/05/12	Brown rice improves the non-alcoholic fatty liver disease via alter the hepatic vitamin A metabolism
14.	2018/05/12	Soybean meal prevents high fat diet-induced hepatic steatosis via activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ)/Small heterodimer partner (SHP) pathway in Sprague-Dawley rats
15.	2017/10/14	Effect of lactic acid bacteria extract fementation products on gut microbiotation rats fed a high fat diet (ISSAAS 2017, International Congress and General Meeting of International Society for Southeast Asian Agricultural Sciences)
16.	2017/10/14	PREGELATINIZED BROWN RICE CAUSES HEPATIC VITAMIN A METABOLIC (ISSAAS 2017, International Congress and General Meeting of International Society for Southeast Asian Agricultural Sciences)
17.	2017/05/21	Renal quinolinic acid accumulation induces noninflammatory renal impairment
18.	2017/05/20	Effects of iron deficiency on intracellular kinetics of CYPs, vitamin D hydroxylase
19.	2017/05/20	Mechanism analysis of the transient glucose metabolism abnormality in Eker rat(TSC2+/-)
20.	2017/05/20	Pregelatinized brown rice ameliorates steatosis without insulin involvement
21.	2016/11/06	EFFECT OF LACTIC ACID BACTERIA EXTRACT FEMENTATION PRODUCTS ON GUT MICROBIOTAIN RATS FED A HIGH FAT DIET (ISSAAS 2016, International Congress and General Meeting of International Society for Southeast Asian Agricultural Sciences)
22.	2016/11/06	PREGELATINIZED BROWN RICE IMPROVE PANCREATIC DISORDER BY DECREASING SERUM INSULIN LEVEL IN OBESE MODEL ZUCKER FATTY RAT (ISSAAS 2016, International Congress and General Meeting of International Society for Southeast Asian Agricultural Sciences)
23.	2016/05/15	Iron deficiency induces cell senescence by increasing oxidative stress
24.	2016/03/30	Dynamic imaging of fluorescently labeled resveratrol in Caco-2 Cells
25.	2016/03/29	Relationship of cell senescence and autophagy in iron deficiency
26.	2015/11/22	Iron deficiency induced autophagy throughactivation of Nrf2/Keap1 system and phosphorylationof p62 (Thr351) against oxidative stress. (6th International Conference on Food Factors (ICoFF2015))
27.	2015/09/19	QPRT KNOCKOUT MICE CAUSES RENAL IMPAIRMENT (The 14th International Society for Tryptophan Research (ISTRY) Conference)
28.	2015/09/10	Calcium signaling induces TSC2 phosphorylation independently of Akt (2015 International Tuberous Sclerosis Complex Research Conference: From Treatment to Prevention)
29.	2015/09/10	Tuberous sclerosis complex 1(TSC1) regulates the Caveolae mediated endocytosis via controlling the Rab5 activity (2015 International Tuberous Sclerosis Complex Research Conference: From Treatment to Prevention)
30.	2015/05/15	Pregelatinized brown rice ameliorates hepatic disorder and pancreatitis in obese model rats (12th Asian Congress of Nutrition (ACN))
31.	2014/12/10	Hepatoprotective effects of pregelatinized rice (White and Brown rice) in obese model rats (East Asia Conference on Standardization of Rice Function (The 3rd International Symposium on Rice and Disease Prevention, Pre-symposium of 9th Asia Pacific Conference on Clinical Nutrition))
32.	2014/12/10	Lipid metabolism improvement effects of pregelatinized rice (white and brown rice) in obese model rats (East Asia Conference on Standardization of Rice Function (The 3rd International Symposium on Rice and Disease Prevention, Pre-symposium of 9th Asia Pacific Conference on Clinical Nutrition))
33.	2014/06/01	Lactic acid bacterium fermented soybean product (FiLact) can reduce the serum triglyceride concentration through activating Nrf2 pathway
34.	2014/06/01	The effect of Quinolinic Acid on renal erythropoietin expression
35.	2014/05/31	A deficiency of Vitamin B12 suppresses the Cholesterol Catabolism through the decreaseding SIRT1 expresssion
36.	2014/05/31	DNA Microarray Analysis of liver in TSC1^+/-mice.
37.	2014/05/31	The analysis of GSK3-regulated AMPK activity in the brain
38.	2014/05/31	The exploratiom of the novel compounds that regulate AMPK
39.	2014/05/30	Analysis of calcium-signaling to mTOR phosphorylation via TSC2.
40.	2014/05/15	Renal accumulation of Quinolinic Acid induces renal fibrosis and decreases erythropoietin expression (14th Asian Pacific Congress of Nephrology （APCN2014）)
41.	2014/05/15	Vitamin B₁₂ deficiency inhibits megalin, cubilin-mediated endocytosis and suppresses reabsorption of vitamin A in the kidney (14th Asian Pacific Congress of Nephrology （APCN2014）)
42.	2014/04/13	Imaging of Fluorescently labeled Olive Polyphenol Hydroxytyrosol in Caco-2 Cells (Focus on Microscopy 2014 (27th International Conference on 3D Image Processing in Microscopy))
43.	2014/04/13	Imaging of the effect of vitamin B12 deficiency on reabsorption of vitamin A in the kidney (Focus on Microscopy 2014 (27th International Conference on 3D Image Processing in Microscopy))
44.	2014/03/28	3-Hydroxytyrosol, but not tyrosol, plays a key role for suppressing osteoclast differentiation
45.	2013/05/26	Bacterial degradation of melanoidin
46.	2013/05/26	Comprehensive analysis of the effects of lactic acid bacteria fermentation soy (FiLact ®) intake on the variation of gene expression in the liver under conditions of high-fat diet
47.	2013/05/26	Effects of an iron-deficient diet on the redox homeostasis of mice various organs
48.	2013/05/25	Mutated TSC modulates the Pentose Phosphate Pathway through activating G6PD
49.	2013/03/26	Effects of an iron-deficient diet on the redox homeostasis of mouse heart
50.	2013/03/26	Research on the melanoidin decolorization by microorganism
51.	2012/12/16	Analysis of SIRT1 activation by ketogenic diet
52.	2012/12/16	Analysis of the mechanism of Rac1 activation through mutant TSC2 (The 85th Annual Meeting of the Japanese Biochemical Society)
53.	2012/12/16	The effect of vitamin B-12 on vitamin A transport (The 85th Annual Meeting of the Japanese Biochemical Society)
54.	2012/12/15	Effect of Vitamin B-12 deficiency on reabsorption of vitamin D and phosphorus in the Kidney
55.	2012/09/17	Separation of microbes to degrade melanoidin formed in cane molasses (11th International Symposium on the Maillard Reaction (ISMR) Nancy)
56.	2012/04/03	Correlative light and electron microscopy studies on human colorectal cancer cells in vitro. (Focus on Microscopy 2012.（25th International Conference on 3D Image Processing in Microscopy, 24th International Conference on Confocal Microscopy）)
57.	2011/03/26	Effect of mutant TSC2 on metabolism via NADPH
58.	2011/03/26	Rac1 activity through TSC2 mutant
59.	2009/10/24	AICAR inhibits apoptosis via AMPK/TSC2/mTOR pathway in Cos-1 cells.
60.	2009/10/24	CaM-dependent alteration of intracellular localizationof tumor suppressor proteins (TSC1, TSC2)
61.	2009/10/24	Caveolin-1 directly interacts with TSC1.
62.	2009/09/24	Calmodulin-Dependent Alteration of Intracellular Localization of Tumor Suppressor Proteins (TSC1, TSC2) (International Tuberous Sclerosis Complex (TSC) Conference: From DNA to Human Therapies)
63.	2009/09/24	Phosphorylation of TSC1 at Residue T417 Results in Mitochondrial Localization and HSP70-Dependent Regulation of Apoptosis (International Tuberous Sclerosis Complex (TSC) Conference: From DNA to Human Therapies)
64.	2007/10/30	Analysis of Gene Expression Related to the One Carbon Metabolic Pathway and DNA Methylation Status in the Rat Livers During Vitamin B-12-Deficiency. (21st International Mammalian Genome Conference　（第21回IMGC2007　国際哺乳類ゲノム会議）)
65.	2007/09/24	Calmodulin (CaM) dependent dissociation of tuberin from membrane. (TUBEROUS SCLEROSIS COMPLEX : FROM GENES TO NEW THERAPEUTICS)
66.	2007/09/24	Direct Interaction of TSC1 gene product hamartin to Hsp70 (TUBEROUS SCLEROSIS COMPLEX：FROM GENES TO NEW THERAPEUTICS)
67.	2007/09/24	Tuberin regulates Rac1 activity and ROS production (TUBEROUS SCLEROSIS COMPLEX：FROM GENES TO NEW THERAPEUTICS)
68.	2006/07/07	Analysis of Huntington's disease transgenic mice based on "Quinolinate hypothesis" (The 11th International Meeting of International Study Group for Tryptophan research (ISTRY-2006))
69.	2006/06/20	Analysis of the relationship between THP excretion and sodium ion reabsorption in rat kidney (20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress)
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■ Committee and society

1.	2023/06/29～	Okayama Bioactive Research Society Secretary
2.	2022/04/01	Frontiers in Neuroscience Review Editor for Neuroenergetics, Nutrition and Brain Health