Faculty Information - Motohiro Takeya

（Last updated : 2024-04-04 14:10:27）

Motohiro Takeya
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science

Position Professor

Basic Information

■ Research Fields

Experimental pathology, Respiratory medicine, Human pathology, Metabolism and endocrinology (Key Word：SR-AI, II(CD204),ACAT-1,CD204,LOX-1,CD36,LOX-1(Lectin-like oxidized LDL receptor-1),MCP-1,corosolic acid,SR-AI,II)

Academic Achievements

■ Selected Publications

1.	2023/04	Article	Testicular teratomagenesis from primordial germ cells with overexpression of germinal center-associated nuclear protein Cancer Science 114(4),pp.1729-1739 (Collaboration)
2.	2023/01	Article	Senescence and macrophages: role of macrophages in age-related chronic diseases pp.20-25 (Single)
3.	2018/11	Article	Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions. Drug delivery pp.1067-1077 (Collaboration)
4.	2018/07	Article	Positive correlation between the density of macrophages and T-cells in undifferentiated sarcoma. Medical molecular morphology (Collaboration)
5.	2018/06	Article	CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma. Cancer research pp.3255-3266 (Collaboration)
6.	2018/05	Article	Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure. The Journal of investigative dermatology (Collaboration)
7.	2017/04	Article	Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages. Journal of clinical and experimental hematopathology : JCEH pp.15-20 (Collaboration)
8.	2017/04	Article	The cell-cell interaction between tumor-associated macrophages and small cell lung cancer cells is involved in tumor progression via STAT3 activation. Lung cancer (Amsterdam, Netherlands) pp.22-32 (Collaboration)
Display 5 items
Display all(8)

■ Grants

1.	2011～2013	Development of new therapeutic strategies for regulating macrophage activation by natural compounds (Key Word : )
2.	2008～2010	Functional analysis of the ACAT-1-positive late endosomes in cholesterol-rich macrophages (Key Word : )
3.	2008～2010	ROLE OF SCAVENGER RECEPTORS IN MACROPHAGE ACTIVATION AND THEIR APPLICATION FOR DIAGNOSIS AND THERAPY (Key Word : )
4.	2007～2010	Academic project of oncogenic factors in malignant tumors and the related diseases in northeast China (Key Word : )
5.	2005～2007	Identification and characterization of novel vesicular organelle appearing hyperlipidemic human macrophages (Key Word : )
6.	2005～2007	Oxidative stress regulation through NO-induced nucleic acid nitration in pulmonary diseases (Key Word : )
7.	2004～2007	Application of CD204 (scavenger receptor) to histopathological diagnosis and production of new anti-macrophage antibodies (Key Word : )
8.	2004～2005	Elucidation of the mechanisms for intracellular accumulation of cholesterol ester and its application to therapies. (Key Word : )
9.	2001～2003	IN VIVO EXPRESSION AND PATHOLOGICAL ROLES OF SCAVENGER RECEPTOR FAMILY MOLECULES (Key Word : )
10.	2001～2002	Roles of CD36 and SR-BI as novel AGE-receptors (Key Word : )
11.	2000～2002	Role of scavenger receptors in atherogenesis and development of new therapeutic methods (Key Word : )
12.	1998～1999	Development of quantitative analysis method of the atherosclerotic lesions in gene targeted mice (Key Word : )
13.	1998～2000	Macrophage scavenger receptor as a new macrophage marker (Key Word : )
14.	1996～1998	Pathological Significance of Macrophage Scavenger Receptors (Key Word : )
15.	1996～1997	Role of Monocyte Chemoattractant Protein-1 in Various Pathological Conditions (Key Word : )
Display 5 items
Display all(15)