サカイ ジュンイチ   Sakai Junichi
  酒井 淳一
   所属   スポーツ健康学部
   職種   教授
言語種別 英語
発行・発表の年月 2021/01
形態種別 研究論文(学術雑誌)
標題 Effects of Abietane diterpenes from Rosmarinus officinalis on guinea pig hearts
執筆形態 共著
掲載誌名 名古屋学院大学論集 人文・自然科学篇
掲載区分国内
巻・号・頁 第57巻(第2号),pp.29-35
著者・共著者 青柳裕、一幸生、竹谷孝一、酒井淳一、堀田芳弘
概要 A plant in the Lamiaceae family, rosemary ( Rosmarinus officinalis ) is a perennial shrub native to the Mediterranean region. The current study used right atrial specimens from guinea pigs to assess the biological activity of 3 catechol diterpenes with an abietane skeleton―carnosic acid (CA ― 1), demethylsalvicanol (DS ― 1), and carnosol (CN ― 1)―contained in rosemary. Administration of CA ― 1 had a positive inotropic effect (PIE) while administration of CN ― 1 conversely had a negative inotropic effect (NIE). Administration of DS ― 1 resulted in no changes in myocardial contractility.
Administration of CA ― 1 or DS ― 1 did not result in significant changes in heart rate. However, administration of CN ― 1 had a negative chronotropic effect (NCE), and administration of CN ― 1 at a final concentration of 10 - 4 M caused cardiac arrest. In addition, the PIE of CA ― 1 was inhibited by prior administration of the phosphodiesterase (PDE) inhibitor IBMX (5 μM).