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サカイ ジュンイチ
Sakai Junichi
酒井 淳一 所属 スポーツ健康学部 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2021/01 |
| 形態種別 | 研究論文（学術雑誌） |
| 標題 | Effects of ent -Kaurene diterpenes from Rabdosia excisa on the cardiac function of guinea pigs |
| 執筆形態 | 共著 |
| 掲載誌名 | 名古屋学院大学論集 人文・自然科学篇 |
| 掲載区分 | 国内 |
| 巻・号・頁 | 第57巻(第2号),pp.19-27 |
| 著者・共著者 | 齊藤久美子、青柳裕、一幸生、竹谷孝一、桂明玉、金永日、李文、堀田芳弘 |
| 概要 | The medicinal plant Rabdosia excisa in the Lamiaceae family is found in Northeastern China and is used to treat a fever due to a cold, mastitis, arthralgia, and bruises[1]. A previous study reported that an aqueous extract from that plant yielded ent -kaurene diterpenes with antitumor action. In addition, diterpenes have been used to synthesize analogs in relatively large quantities, and their structureactivity relationship in terms of cytotoxic activity[2] and inhibition of the activation of the intracellular transcription factor NF-κB[3] has been examined. Various studies have also examined ent -kaurene diterpenes[4] ― [7]. Three diterpenes―kamebakaurin (1), kamebanin (2), and excisanin A (3)―can be obtained in relatively large quantities from R. excisa . The current study examined the effects of those diterpenes on cardiac function in guinea pigs. Some of those findings are reported here. |