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タグチ レイナ
TAGUCHI REINA
田口 玲奈 所属 鍼灸学部 鍼灸学科 職種 准教授 |
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| 言語種別 | 日本語 |
| 発行・発表の年月 | 2004 |
| 形態種別 | 研究論文 |
| 標題 | Corticotro-pin-releasing factor and interleukin-1βare involved in the elec-troacupunc-ture-induced analgesic effect on inflammatory pain elicited by car-rageenan. |
| 執筆形態 | 共著 |
| 掲載誌名 | Am. J. Chin. Med. |
| 巻・号・頁 | 32(2),269-279頁 |
| 担当範囲 | 本研究の施行から論文作成まで全てを担当した。 |
| 著者・共著者 | Sekido R、Ishimaru K、Masakazu S |
| 概要 | We investigated whether endogenous pe-ripheral corticotropin-releasing factor (CRF) or interleukin-1β(IL-1) participated in EAA during hyperalgesia elicited by car-rageenan-induced inflammation. PPT eleva-tions produced by EA were dose-dependently antagonized by local i.pl. injection of α-helical CRF or IL-1ra. This PPT elevation was not influenced by i.v. injection of α-helical CRF or IL-1ra. These findings suggest that peripheral CRF or IL-1 participate in EAA during hyperalgesia. The release of CRF or IL-1 elicited by EA may trigger the release of opioid peptides within inflamed tissue which may activate peripheral opioid receptors and inhibit the pain. |