アオキ ユウジ
Yuji.AOKI
青木 雄次
- 所属 松本大学大学院 健康科学研究科 健康科学専攻
- 松本大学 人間健康学部 健康栄養学科
- 職種 教授
| 発表年月日 | 2018/12/02 |
| 発表テーマ | Possibly preferable changes in serum levels of adiponectin and amyloid beta peptides 6 months after add-on treatment of half-dose pioglitazone in elderly Japanese patients with type 2 diabetes. |
| 会議名 | 18th International Congress of Endocrinology |
| 主催者 | International Society of Endocrinology |
| 学会区分 | 国際学会 |
| 発表形式 | ポスター |
| 単独共同区分 | 単独 |
| 開催地名 | Cape Town, South Africa |
| 発表者・共同発表者 | Yuji Aoki |
| 概要 | Since pioglitazone, a peroxisome proliferator-activated receptor γ agonist, has been suggested to have potential for the treatment of Alzheimer’s disease, serum levels of amyloid beta peptides (β1-40 and β1-42) were assessed in elderly diabetic patients treated with pioglitazone. There was a positive correlation between serum amyloid β1-40 and HMW adiponectin levels at baseline, and the ratio of amyloid β1-42 to β1-40 tended to be decreased after the add-on treatment of half-dose pioglitazone especially in female patients. These findings may suggest that pioglitazone and/or adiponectin could have the potential to prevent Alzheimer’s disease. |