アオキ ユウジ
Yuji.AOKI
青木 雄次
- 所属 松本大学大学院 健康科学研究科 健康科学専攻
- 松本大学 人間健康学部 健康栄養学科
- 職種 教授
| 言語種別 | 英語 |
| 発行・発表の年月 | 2017/02 |
| 形態種別 | 速報，短報，研究ノート等（学術雑誌） |
| 査読 | 査読あり |
| 標題 | Sodium-glucose co-transporter 2 inhibitors could improve the bioavailability of vitamin C at the kidney in diabetes treatment. |
| 執筆形態 | 共著 |
| 掲載誌名 | Cellular & Molecular Medicine |
| 掲載区分 | 国外 |
| 出版社・発行元 | iMedPub |
| 巻・号・頁 | 3(2),pp.7-8 |
| 総ページ数 | 2 |
| 担当範囲 | Aoki Y researched the literature, and wrote the manuscript. |
| 著者・共著者 | Yuji Aoki, Masato Aoki, David JA Jenkins |
| 概要 | It is known that plasma (serum) vitamin C level is lowered in diabetic patients by some mechanisms including renal loss. Vitamin C and glucose filtered from the glomerulus are presumed to be reabsorbed at the renal proximal tubule by sodium-vitamin C co-transporter (SVCT) 1 and sodium-glucose co-transporter (SGLT) 2, respectively. At the presence of SGLT 2 inhibitors, the reabsorption of ascorbic acid could be increased by utilizing the energy saved by the inhibition of SGLT 2. It seems plausible that reabsorbed ascorbic acid protects renal proximal tubular cells from reactive oxygen species and exits the cells as dehydroascorbic acid, as indicated in the neurons. |