Faculty Information - 青木　学

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Academic Achievements

Selected Publications

Selected Presentations

（Last updated : 2024-01-31 15:36:51）

青木　学
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science

Kumamoto Health Science University Graduate School Division of Health Sciences, Graduate School of Health Sciences

Position Professor

Academic Achievements

■ Selected Publications

1.	2023/07/12	Article	GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants Science Advances (Collaboration)
2.	2023/03	Book	Novel anti-HIV-1 agents in development pp.719-725 (Collaboration)
3.	2023	Article	Identification of SARS-CoV-2 Mpro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2 Nature Communications (Collaboration)
4.	2022	Article	Design, Synthesis and X-Ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-Furofuran Derivatives as P2 Ligands. ChemMedChem (Collaboration)
5.	2020	Article	Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity. Scientific Reports (Collaboration)
6.	2019	Article	A novel HIV-1 protease inhibitor, GRL-044, has potent activity against various HIV-1s with an extremely high genetic barrier to the emergence of HIV-1 drug resistance. Global Health & Medicine 1,pp.36--48 (Collaboration)
7.	2019	Article	Novel protease inhibitors containing C-5-modified bis-THF and aminobenzothiazole as P2 and P2' ligands that exert potent antiviral activity against highly multidrug-resistant HIV-1 with high genetic barrier against the emergence of drug resistance. Antimicrobial Agents and Chemotherapy 25(63(8)),pp.e00372--19 (Collaboration)
8.	2018	Article	Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance. 6(9(2)),pp.e02425--17 (Collaboration)
9.	2017	Article	A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency. eLife 17(6),pp.e28020 (Collaboration)
10.	2015	Article	C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir. Jornal of Virology 18(90(5)),pp.01829--15 (Collaboration)
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■ Selected Presentations

2023/11/07

GRL-142 Binds to and Impairs HIV-1-Integrase-Nuclear Localization Signal and Exerts Potent Activity against INSTI-Resistant HIV-1 (24th Kumamoto AIDS Seminar)