| 基本情報 |
■ 最終学歴
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■ 保有学位
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| 研究業績 |
■ 著書・論文等
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1. |
2023/07/12 |
論文 |
GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants Science Advances （共著） |
|
2. |
2023/03 |
著書 |
臨床開発のパイプラインにある新規化合物 医学のあゆみ 284(9),719-725頁 （共著） |
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3. |
2023 |
論文 |
Identification of SARS-CoV-2 Mpro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2 Nature Communications （共著） |
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4. |
2022 |
論文 |
Design, Synthesis and X-Ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-Furofuran Derivatives as P2 Ligands. ChemMedChem （共著） |
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5. |
2020 |
論文 |
Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity. Scientific Reports （共著） |
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6. |
2019 |
論文 |
A novel HIV-1 protease inhibitor, GRL-044, has potent activity against various HIV-1s with an extremely high genetic barrier to the emergence of HIV-1 drug resistance. Global Health & Medicine 1,pp.36--48 （共著） |
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7. |
2019 |
論文 |
Novel protease inhibitors containing C-5-modified bis-THF and aminobenzothiazole as P2 and P2' ligands that exert potent antiviral activity against highly multidrug-resistant HIV-1 with high genetic barrier against the emergence of drug resistance. Antimicrobial Agents and Chemotherapy 25(63(8)),pp.e00372--19 （共著） |
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8. |
2018 |
論文 |
Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance. 6(9(2)),pp.e02425--17 （共著） |
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9. |
2017 |
論文 |
A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency. eLife 17(6),pp.e28020 （共著） |
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10. |
2015 |
論文 |
C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir. Jornal of Virology 18(90(5)),pp.01829--15 （共著） |
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5件表示
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全件表示(10件)
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■ 学会発表
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■ 受託研究・競争的資金
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