(最終更新日:2022-05-20 15:21:36)
  アオキ マナブ
  青木 学
   所属   熊本保健科学大学  保健科学部 医学検査学科
   熊本保健科学大学大学院  保健科学研究科 保健科学専攻
   職位  教授
基本情報
■ 最終学歴
熊本大学大学院自然科学研究科博士前期課程修了
■ 保有学位
1. 理学修士、医学博士
研究業績
■ 著書・論文等
1. 2019 論文  A novel HIV-1 protease inhibitor, GRL-044, has potent activity against various HIV-1s with an extremely high genetic barrier to the emergence of HIV-1 drug resistance. Global Health & Medicine 1,pp.36--48 (共著) 
2. 2019 論文  Novel protease inhibitors containing C-5-modified bis-THF and aminobenzothiazole as P2 and P2' ligands that exert potent antiviral activity against highly multidrug-resistant HIV-1 with high genetic barrier against the emergence of drug resistance. Antimicrobial Agents and Chemotherapy 25(63(8)),pp.e00372--19 (共著) 
3. 2018 論文  Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance.  6(9(2)),pp.e02425--17 (共著) 
4. 2017 論文  A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency. eLife 17(6),pp.e28020 (共著) 
5. 2015 論文  C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir. Jornal of Virology 18(90(5)),pp.01829--15 (共著)