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Osamu HIRUTA
Department Kumamoto Health Science University , Kumamoto Health Science University Graduate School Division of Health Sciences, Graduate School of Health Sciences Position |
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| Language | English |
| Publication Date | 1991/02 |
| Type | |
| Peer Review | Peer reviewed |
| Title | Relationship between Sugar Consumption and Tricaboxylic Acid Cycle Enzyme Activity in a High Bialaphos-Producing Strain : Studies on the Production of Bialaphos(II). |
| Contribution Type | |
| Journal | Journal of fermentation and bioengineering |
| Journal Type | Japan |
| Publisher | Society for Biotechnology, Japan |
| Volume, Issue, Page | 71(2),pp.110-113 |
| Total page number | 4 |
| Author and coauthor | Hidehi Takebe, Mihoko Matsunaga, Osamu Hiruta, Atsuyuki Satoh, Hideo Tanaka |
| Details | The biosynthesis of bialaphos produced by Streptomyces hygroscopicus, proceeds through the degradation of glucose to phosphoenol pyruvate, the formation of a CP bond, acetic addition by acetyl-CoA and alanine addition. Therefore, bialaphos formation is considered to be closely related to glucose metabolism. As the result, it is suggested that the highly productive strain suppresses the flow from acetyl-CoA and pyruvate (as substrates of bialaphos) to the TCA cycle, and efficiently directs these substrates to the secondary metabolism by activation of the glyoxylic acid cycle, resulting in a high rate of bialaphos production in this strain. |