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ヒルタ オサム
Osamu HIRUTA
蛭田 修 所属 熊本保健科学大学 品質保証・精度管理学共同研究講座 熊本保健科学大学大学院 保健科学研究科 保健科学専攻 職位 特命教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 1991/02 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Relationship between Sugar Consumption and Tricaboxylic Acid Cycle Enzyme Activity in a High Bialaphos-Producing Strain : Studies on the Production of Bialaphos(II). |
| 執筆形態 | 共著 |
| 掲載誌名 | Journal of fermentation and bioengineering |
| 掲載区分 | 国内 |
| 出版社・発行元 | Society for Biotechnology, Japan |
| 巻・号・頁 | 71(2),pp.110-113 |
| 総ページ数 | 4 |
| 著者・共著者 | Hidehi Takebe, Mihoko Matsunaga, Osamu Hiruta, Atsuyuki Satoh, Hideo Tanaka |
| 概要 | The biosynthesis of bialaphos produced by Streptomyces hygroscopicus, proceeds through the degradation of glucose to phosphoenol pyruvate, the formation of a CP bond, acetic addition by acetyl-CoA and alanine addition. Therefore, bialaphos formation is considered to be closely related to glucose metabolism. As the result, it is suggested that the highly productive strain suppresses the flow from acetyl-CoA and pyruvate (as substrates of bialaphos) to the TCA cycle, and efficiently directs these substrates to the secondary metabolism by activation of the glyoxylic acid cycle, resulting in a high rate of bialaphos production in this strain. |