Osamu HIRUTA
Department Kumamoto Health Science University , Kumamoto Health Science University Graduate School Division of Health Sciences, Graduate School of Health Sciences Position |
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Language | English |
Publication Date | 1997/01 |
Type | |
Peer Review | Peer reviewed |
Title | Application of Maxblend Fementor for Microbial Processes |
Contribution Type | |
Journal | Journal of fermentation and bioengineering |
Journal Type | Japan |
Volume, Issue, Page | 83(1),pp.79-86 |
Total page number | 8 |
Author and coauthor | Osamu Hiruta, Kenji Yamamura, Hidehi Takebe, Takafumi Futamura, Katsuharu Iinuma, Hideo Tanaka |
Details | Application of the Maxblend impeller to a bioreactor (MBF) was investigated. In comparison with turbine impeller fermentor (TBN). During the fermentative production of hyaluronic acid in TBN, the pH in some parts of the fermentor was lower than the optimum pH for hyaluronic acid production. On the other hand, when MBF was used, the pH distribution inside the fermentor was homogeneous throughout the cultivation, resulting to about 20% increase in the hyaluronic acid productivity compared with a TBN. In the case of γ-linolenic acid (GLA) production by Mortierella ramanniana, although the power consumption for liquid agitation was lower in the MBF equipped with a spiral sparger than in the TBN, small hard pellets were formed in former and this resulted in a higher GLA content of the lipid. This was because the shear stress distribution was more uniform inside the MBF than in the TBN under the same agitation conditions. |