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SAKAMOTO Chiyomi
Department Kumamoto Health Science University , Position |
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| Language | English |
| Publication Date | 2018/10/12 |
| Type | |
| Peer Review | Peer reviewed |
| Title | Endocrine therapy-resistant breast cancer model cells are inhibited by soybean glyceollin I through Eleanor non-coding RNA. |
| Contribution Type | |
| Journal | Scientific Reports. |
| Journal Type | Another Country |
| Responsible for | Cell culture and drug treatment,Fluorescence in situ hybridization (FISH),Immunofluorescence,Cell growth assay |
| Author and coauthor | Tatsuro Yamamoto#, Chiyomi Sakamoto#, Hiroaki Tachiwana, Mitsuru Kumabe, Toshiro Matsui, Tadatoshi Yamashita, Masatoshi Shinagawa,Koji Ochiai,Noriko Saitoh, Mitsuyoshi Nakao |
| Details | We prepared another polyphenol, glyceollin I from stressed soybeans, and identified it as a major inhibitor of the Eleanor RNA cloud and ESR1 mRNA transcription. The inhibition was independent of ER, unlike one by resveratrol. This was consistent with a distinct tertiary structure of glyceollin I for ER binding. Glyceollin I preferentially inhibited the growth of LTED cells and induced apoptosis. Our results suggest that glyceollin I has a novel role in LTED cell inhibition through Eleanors. In other words, LTED cells or endocrine therapy-resistant breast cancer cells may be ready for apoptosis, which can be triggered with polyphenols both in ER-dependent and ER-independent manners. |