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サカモト チヨミ
SAKAMOTO Chiyomi
坂本 智代美 所属 熊本保健科学大学 生物毒素・抗毒素共同研究講座 職位 特命助教 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2018/10/12 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Endocrine therapy-resistant breast cancer model cells are inhibited by soybean glyceollin I through Eleanor non-coding RNA. |
| 執筆形態 | 共著 |
| 掲載誌名 | Scientific Reports. |
| 掲載区分 | 国外 |
| 担当範囲 | Cell culture and drug treatment,Fluorescence in situ hybridization (FISH),Immunofluorescence,Cell growth assay |
| 著者・共著者 | Tatsuro Yamamoto#, Chiyomi Sakamoto#, Hiroaki Tachiwana, Mitsuru Kumabe, Toshiro Matsui, Tadatoshi Yamashita, Masatoshi Shinagawa,Koji Ochiai,Noriko Saitoh, Mitsuyoshi Nakao |
| 概要 | We prepared another polyphenol, glyceollin I from stressed soybeans, and identified it as a major inhibitor of the Eleanor RNA cloud and ESR1 mRNA transcription. The inhibition was independent of ER, unlike one by resveratrol. This was consistent with a distinct tertiary structure of glyceollin I for ER binding. Glyceollin I preferentially inhibited the growth of LTED cells and induced apoptosis. Our results suggest that glyceollin I has a novel role in LTED cell inhibition through Eleanors. In other words, LTED cells or endocrine therapy-resistant breast cancer cells may be ready for apoptosis, which can be triggered with polyphenols both in ER-dependent and ER-independent manners. |