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Kensaku Anraku
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science Kumamoto Health Science University Graduate School Division of Health Sciences, Graduate School of Health Sciences Position Professor |
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| Language | English |
| Publication Date | 2010/06 |
| Type | |
| Peer Review | Peer reviewed |
| Title | Highly sensitive analysis of the interaction between HIV-1 Gag and phosphoinositide derivatives based on surface plasmon resonance. |
| Contribution Type | |
| Journal | Biochemistry |
| Publisher | アメリカ化学会（ACS |
| Volume, Issue, Page | 49,pp.5109-5116 |
| Responsible for | 研究全般、化合物合成、活性評価、論文作成 |
| Authorship | Lead author |
| Author and coauthor | Kensaku Anraku, Ryota Fukuda, Nobutoki Takamune, Shogo Misumi, Yoshinari Okamoto, Masami Otsuka and Mikako Fujita. |
| Details | イノシトールリン酸及びイノシトールリン脂質とHIV-1 Gag関連蛋白質の結合解析を実施し、結合親和性（KD）を算出した。結果として、イノシトールリン脂質とGag蛋白質との結合は、イノシトールリン酸部位と脂質部位の両方が必要であり、特に疎水性相互作用が重要な役割を果たすことを証明した。 |