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Rui Yamaguchi
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science Kumamoto Health Science University Graduate School Division of Health Sciences, Graduate School of Health Sciences Position Associate Professor |
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| Language | English |
| Publication Date | 2016/02 |
| Type | |
| Peer Review | Peer reviewed |
| Title | Roles of myeloperoxidase and GAPDH in interferon-gamma production of GM-CSF-dependent macrophages |
| Contribution Type | |
| Journal | Heliyon. |
| Journal Type | Japan |
| Volume, Issue, Page | 2:e00080 |
| Total page number | 14 |
| Authorship | Lead author |
| Author and coauthor | Yamaguchi R, Yamamoto T, Sakamoto A, Ishimaru Y, Narahara S, Sugiuchi H, Yamaguchi Y |
| Details | Interferon (IFN)-gamma is highly expressed in atherosclerotic lesions and may have an important role in atherogenesis. Myeloperoxidase (MPO), the most abundant protein in neutrophils, is a marker of plaque vulnerability and a possible bridge between inflammation and cardiovascular disease. Granulocyte-macrophage colony-stimulating factor (GM-CSF) has also been implicated in the pathogenesis of atherosclerosis. The present study investigated the role of neutrophil activation in atherosclerosis. Adherent macrophages were obtained from primary cultures of human mononuclear cells. |