|
Rui Yamaguchi
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science Kumamoto Health Science University Graduate School Division of Health Sciences, Graduate School of Health Sciences Position Associate Professor |
|
| Language | English |
| Publication Date | 2016/03 |
| Type | |
| Peer Review | Peer reviewed |
| Title | Cholera toxin B subunit pentamer reassembled from Escherichia coli inclusion bodies for use in vaccination |
| Contribution Type | |
| Journal | Vaccine. |
| Journal Type | Another Country |
| Volume, Issue, Page | 34,pp.1268-1274 |
| Total page number | 6 |
| Author and coauthor | Tamaki Y, Harakuni T, Yamaguchi R, Miyata T, Arakawa T |
| Details | The cholera toxin B subunit (CTB) is secreted in its pentameric form from Escherichia coli if its leader peptide is replaced with one of E. coli origin. However, the secretion of the pentamer is generally severely impaired when the molecule is mutated or fused to a foreign peptide. Therefore, we attempted to regenerate pentameric CTB from the inclusion bodies (IBs) of E. coli. |