Rui Yamaguchi
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science Kumamoto Health Science University Graduate School Division of Health Sciences, Graduate School of Health Sciences Position Associate Professor |
|
Language | English |
Publication Date | 2019/06 |
Type | |
Peer Review | Peer reviewed |
Title | Di-(2-Ethylhexyl) Phthalate Promotes Release of Tissue Factor-Bearing Microparticles From Macrophages via the TGFβ1/Smad/PAI-1 Signaling Pathway |
Contribution Type | |
Journal | The American Journal of the Medical Sciences |
Journal Type | Another Country |
Volume, Issue, Page | 357(6),pp.492-506 |
Total page number | 14 |
Authorship | Lead author |
Author and coauthor | Rui Yamaguchi , Arisa Sakamoto , Reona Yamaguchi , Misa Haraguchi , Shinji Narahara , Hiroyuki Sugiuchi , Takahiko Katoh , Yasuo Yamaguchi |
Details | Plasminogen activator inhibitor type 1 promotes formation of endothelial microparticles with procoagulant activity. However, it remains unclear whether di-(2-ethylhexyl) phthalate, a peroxisome proliferator-activated receptor α agonist, influences microparticle formation.Di-(2-ethylhexyl) phthalate promotes formation of tissue factor-bearing microparticles in human M1 macrophages via the transforming growth factor-β1/Smad/ plasminogen activator inhibitor type 1 signaling pathway. |