Rui Yamaguchi
   Department   Kumamoto Health Science University  Department of Medical Technology, Faculty of Health Science
   Kumamoto Health Science University Graduate School  Division of Health Sciences, Graduate School of Health Sciences
   Position   Associate Professor
Language English
Publication Date 2019/06
Type
Peer Review Peer reviewed
Title Di-(2-Ethylhexyl) Phthalate Promotes Release of Tissue Factor-Bearing Microparticles From Macrophages via the TGFβ1/Smad/PAI-1 Signaling Pathway
Contribution Type
Journal The American Journal of the Medical Sciences
Journal TypeAnother Country
Volume, Issue, Page 357(6),pp.492-506
Total page number 14
Authorship Lead author
Author and coauthor Rui Yamaguchi , Arisa Sakamoto , Reona Yamaguchi , Misa Haraguchi , Shinji Narahara , Hiroyuki Sugiuchi , Takahiko Katoh , Yasuo Yamaguchi
Details Plasminogen activator inhibitor type 1 promotes formation of endothelial microparticles with procoagulant activity. However, it remains unclear whether di-(2-ethylhexyl) phthalate, a peroxisome proliferator-activated receptor α agonist, influences microparticle formation.Di-(2-ethylhexyl) phthalate promotes formation of tissue factor-bearing microparticles in human M1 macrophages via the transforming growth factor-β1/Smad/ plasminogen activator inhibitor type 1 signaling pathway.