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Rui Yamaguchi
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science Kumamoto Health Science University Graduate School Division of Health Sciences, Graduate School of Health Sciences Position Associate Professor |
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| Language | English |
| Publication Date | 2021/04 |
| Type | |
| Peer Review | Peer reviewed |
| Title | Ectodomain Shedding May Play a Pivotal Role in Disease Severity in COVID-19 |
| Contribution Type | |
| Journal | Journal of Cellular Signaling |
| Journal Type | Another Country |
| Volume, Issue, Page | 2(2),pp.100-102 |
| Total page number | 3 |
| Authorship | Lead author |
| Author and coauthor | Rui Yamaguchi, Yasuo Yamaguchi |
| Details | Ectodomain shedding mediated by a disintegrin and metalloprotease 10/17 (ADAM10/17) modulates the
function of immune effector cells and may be involved in the novel coronavirus disease COVID-19. Toll-like receptor 7/8 (TLR7/8) recognizes single-strand RNA from viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the virus that causes COVID-19) during the innate immune response, and TLR7/8 agonist activates nicotinamide adenine dinucleotide phosphate (NADPH) oxidase to generate reactive oxygen species (ROS). |