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Rui Yamaguchi
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science Kumamoto Health Science University Graduate School Division of Health Sciences, Graduate School of Health Sciences Position Associate Professor |
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| Language | English |
| Publication Date | 2019/04 |
| Type | |
| Peer Review | Peer reviewed |
| Title | Essential Role of GM-CSF-Dependent Macrophages in Human Autoimmune and Inflammatory Responses |
| Contribution Type | |
| Journal | J Cytokine Biol |
| Journal Type | Another Country |
| Volume, Issue, Page | 4(1) |
| Total page number | 13 |
| Authorship | Lead author |
| Author and coauthor | Rui Yamaguchi, Arisa Sakamoto, Reona Yamaguchi, Misa Haraguchi, Shinji Narahara, Hiroyuki Sugiuchi and Yasuo Yamaguchi |
| Details | Macrophages are important cells in the innate immune system that express toll-like receptors, produce various cytokines, and have a major role in both inflammation and autoimmune diseases. These cells undergo differentiation into GM-CSF-dependent or M-CSF-dependent macrophages in response to influences in the microenvironment. Because there are marked physiological and immunological differences between mice and humans, the inflammatory response of human macrophages is not accurately reproduced by murine models. GM-CSF and M-CSF are factors that promote the differentiation of bone marrow progenitor cells and induce various changes of human macrophage lineages. |