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Rui Yamaguchi
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science Kumamoto Health Science University Graduate School Division of Health Sciences, Graduate School of Health Sciences Position Associate Professor |
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| Language | English |
| Publication Date | 2018/06 |
| Type | |
| Peer Review | Peer reviewed |
| Title | Di-(2-ethylhexyl) phthalate suppresses IL-12p40 production by GM-CSF-dependent macrophages via the PPARα/TNFAIP3/TRAF6 axis after lipopolysaccharide stimulation. |
| Contribution Type | |
| Journal | Human Exp Toxicol |
| Journal Type | Another Country |
| Volume, Issue, Page | 37(6),pp.596-607 |
| Total page number | 12 |
| Authorship | Lead author |
| Author and coauthor | Yamaguchi R, Sakamoto A, Yamamoto T, Narahara S, Sugiuchi H, Hisada A, Katoh T, Yamaguchi Y. |
| Details | Activation of peroxisome proliferator-activated receptor α (PPARα) by di-(2-ethylhexyl) phthalate (DEHP) has an anti-inflammatory effect. This study investigated the potential combined influence of PPARα, tumor necrosis factor α-induced protein 3 (TNFAIP3/A20), and tumor necrosis factor receptor-associated factor 6 (TRAF6) on interleukin (IL)-12p40 production by macrophages exposed to DEHP and stimulated with lipopolysaccharide (LPS). LPS upregulated IL-12p40 expression by granulocyte-macrophage colony-stimulating factor-dependent macrophages (on day 9 of culture), whereas adding DEHP to cultures significantly attenuated the response of IL-12p40 to LPS stimulation.. |