Rui Yamaguchi
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science Kumamoto Health Science University Graduate School Division of Health Sciences, Graduate School of Health Sciences Position Associate Professor |
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Language | English |
Publication Date | 2015/04 |
Type | |
Peer Review | Peer reviewed |
Title | Granulocyte-macrophage colony-stimulating factor primes interleukin-13 production by macrophages via protease-activated receptor-2 |
Contribution Type | |
Journal | Blood Cells Mol Dis. |
Journal Type | Japan |
Volume, Issue, Page | 54,pp.353-359 |
Total page number | 6 |
Author and coauthor | Aoki M, Yamaguchi R, Yamamoto T, Ishimaru Y, Ono T, Sakamoto A, Narahara S, Sugiuchi H, Hirose E, Yamaguchi Y |
Details | Chronic inflammation is often linked to the presence of type 2-polarized macrophages, which are induced by the T helper type 2 cytokines interleukin-4 and interleukin-13 (IL-13). IL-13 is a key mediator of tissue fibrosis caused by T helper type 2-based inflammation. Human neutrophil elastase (HNE) plays a pivotal role in the pathogenesis of pulmonary fibrosis. This study investigated the priming effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on IL-13 expression by macrophages stimulated with HNE. Adherent macrophages were obtained from primary cultures of human mononuclear cells. |