Rui Yamaguchi
   Department   Kumamoto Health Science University  Department of Medical Technology, Faculty of Health Science
   Kumamoto Health Science University Graduate School  Division of Health Sciences, Graduate School of Health Sciences
   Position   Associate Professor
Language English
Publication Date 2015/04
Type
Peer Review Peer reviewed
Title Granulocyte-macrophage colony-stimulating factor primes interleukin-13 production by macrophages via protease-activated receptor-2
Contribution Type
Journal Blood Cells Mol Dis.
Journal TypeJapan
Volume, Issue, Page 54,pp.353-359
Total page number 6
Author and coauthor Aoki M, Yamaguchi R, Yamamoto T, Ishimaru Y, Ono T, Sakamoto A, Narahara S, Sugiuchi H, Hirose E, Yamaguchi Y
Details Chronic inflammation is often linked to the presence of type 2-polarized macrophages, which are induced by the T helper type 2 cytokines interleukin-4 and interleukin-13 (IL-13). IL-13 is a key mediator of tissue fibrosis caused by T helper type 2-based inflammation. Human neutrophil elastase (HNE) plays a pivotal role in the pathogenesis of pulmonary fibrosis. This study investigated the priming effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on IL-13 expression by macrophages stimulated with HNE. Adherent macrophages were obtained from primary cultures of human mononuclear cells.