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Rui Yamaguchi
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science Kumamoto Health Science University Graduate School Division of Health Sciences, Graduate School of Health Sciences Position Associate Professor |
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| Language | English |
| Publication Date | 2016/03 |
| Type | |
| Peer Review | Peer reviewed |
| Title | Substance P enhances tissue factor release from granulocyte-macrophage
colony-stimulating factor-dependent macrophages via the p22phox/β-arrestin 2/Rho A signaling pathway. Blood cells, Molecules. |
| Contribution Type | |
| Journal | Blood Cells Mol Dis. |
| Journal Type | Another Country |
| Volume, Issue, Page | 57,pp.85-90 |
| Total page number | 5 |
| Authorship | Lead author |
| Author and coauthor | Yamaguchi R, Yamamoto T, Sakamoto A, Ishimaru Y, Narahara S, Sugiuchi H, Yamaguchi Y |
| Details | Granulocyte-macrophage colony stimulating factor (GM-CSF) induces procoagulant activity of macrophages. Tissue factor (TF) is a membrane-bound glycoprotein and substance P (SP) is a pro-inflammatory neuropeptide involved in the formation of membrane blebs. This study investigated the role of SP in TF release by GM-CSF-dependent macrophages. SP significantly decreased TF levels in whole-cell lysates of GM-CSF-dependent macrophages. TF was detected in the culture supernatant by enzyme-linked immunosorbent assay after stimulation of macrophages by SP. Aprepitant (an SP/neurokinin 1 receptor antagonist) reduced TF release from macrophages stimulated with SP. |