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ハラグチ ミサ
Misa Haraguchi
原口 実紗 所属 熊本保健科学大学 保健科学部 医学検査学科 職位 講師 |
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| 言語種別 | 日本語 |
| 発行・発表の年月 | 2020/12 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | The role of membrane-embedded DUOX2 on ectodomain shedding via G protein-coupled receptor signaling |
| 執筆形態 | 共著 |
| 掲載誌名 | Journal of Cellular Signaling |
| 掲載区分 | 国外 |
| 担当範囲 | 本人担当部分：共同研究により抽出不可 |
| 著者・共著者 | Rui Yamaguchi, Misa Haraguchi, Reona Yamaguchi, Arisa Sakamoto, Shinji
Narahara, Hiroyuki Sugiuchi and Yasuo Yamaguchi |
| 概要 | Protease-activated receptors (PARs) and the neurokinin 1 receptor (NK1R) belong to the G protein-coupled receptor (GPCR) family. In this review, we focus on the regulatory mechanism of ectodomain shedding by ADAM10/17 metalloprotease via GPCR signaling. PAR2 and NK1R induce membrane blebbing, resulting in phosphatidylserine externalization in the cellular membrane, which is required for ADAM10/17 metalloprotease activation. Membrane-embedded dual oxidase 2 (DUOX2) has NADPH oxidase and peroxidase domains. |