ハラグチ ミサ   Misa Haraguchi
  原口 実紗
   所属   熊本保健科学大学  保健科学部 医学検査学科
   職位   講師
言語種別 日本語
発行・発表の年月 2019/04
形態種別 記事・総説・解説・論説等(学術雑誌)
査読 査読あり
標題 Essential Role of GM-CSF-Dependent Macrophages in Human Autoimmune and Inflammatory Responses
執筆形態 共著
掲載誌名 J Cytokine Biol
掲載区分国外
担当範囲 本人担当部分:共同研究につき抽出不可
著者・共著者 Yamaguchi R, Sakamoto A, Yamaguchi R, Haraguchi M, Narahara S, Sugiuchi H,Yamaguchi Y
概要 Macrophages are important cells in the innate immune system that express toll-like receptors, produce various cytokines, and have a major role in both inflammation and autoimmune diseases. These cells undergo differentiation into GM-CSF-dependent or M-CSF-dependent macrophages in response to influences in the microenvironment. Because there are marked physiological and immunological differences between mice and humans, the inflammatory response of human macrophages is not accurately reproduced by murine models. GM-CSF and M-CSF are factors that promote the differentiation of bone marrow progenitor cells and induce various changes of human macrophage lineages.(