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ハラグチ ミサ
Misa Haraguchi
原口 実紗 所属 熊本保健科学大学 保健科学部 医学検査学科 職位 講師 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2018/08 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Transcription factor specificity protein 1 modulates TGFβ1/Smad signaling to negatively regulate SIGIRR expression by human M1 macrophages stimulated with substance P |
| 執筆形態 | 共著 |
| 掲載誌名 | Cytokine |
| 掲載区分 | 国外 |
| 巻・号・頁 | 108,pp.24-36 |
| 総ページ数 | 13 |
| 担当範囲 | 本人担当部分：共同研究により抽出不可 |
| 著者・共著者 | Yamaguchi R, Sakamoto A, Yamaguchi R, Haraguchi M, Narahara S, Sugiuchi H,Yamaguchi Y |
| 概要 | The stimuli inducing expression of single immunoglobulin IL-1-related receptor (SIGIRR) and the relevant regulatory mechanisms are not well defined. Transforming growth factor β1 (TGFβ1) delays internalization of neurokinin-1 receptor (NK1R) and subsequently enhances cellular signaling. This study investigated the effect of TGFβ1 on SIGIRR protein production by human M1 macrophages in response to stimulation with substance P (SP). SP caused upregulation of SIGIRR expression in a concentration-dependent manner, whereas aprepitant (an NK1R inhibitor) blunted this response. Silencing p38γMAPK or TAK-1 partially attenuated the response to SP stimulation, while TGFβ1/2/3 siRNA dramatically diminished it. SP induced much greater SIGIRR protein production than either lipopolysaccharide (a TLR4 agonist) or resiquimod (a TLR7/8 agonist). |