ハラグチ ミサ   Misa Haraguchi
  原口 実紗
   所属   熊本保健科学大学  保健科学部 医学検査学科
   職位   講師
言語種別 英語
発行・発表の年月 2021/07
形態種別 研究論文(学術雑誌)
査読 査読あり
標題 Adaptive Immunity: The Role of Toll-Like Receptors
執筆形態 共著
掲載誌名 Austin Journal of Allergy
掲載区分国外
巻・号・頁 7(1)
著者・共著者 Rui Yamaguchi, Arisa Sakamoto, Reona Yamaguchi, Misa Haraguchi,
Shinji Narahara, Hiroyuki Sugiuchi and Yasuo Yamaguchi
概要 The central mediators of the adaptive immune response are T cells. The clonal
expansion of T cells required for adaptive immunity results from the innate immune
response, which is triggered by the stimulation of toll-like receptors (TLRs). The
adaptive immune response can cause autoimmune diseases, and Th17 cells are known to
contribute to several autoimmune diseases. Pathogenic Th17 cells are induced by
interleukin 23 (IL-23) and IL-1β. Resiquimod (a TLR7/8 agonist) significantly enhances
IL-23 production by human macrophages, and lipopolysaccharide (a TLR4 agonist)
slightly enhances it. Interestingly, IL-23 levels are significantly attenuated after
sequential stimulation with lipopolysaccharide and resiquimod, indicating cross-talk
between the TLR4 and TLR7/8 signaling pathways. In this review, we discuss the
pivotal role of TLRs in triggering innate immunity and inducing adaptive immunity,
leading to autoimmune diseases.