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Ippei noboruo
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science Position Assistant Professor |
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| Language | English |
| Publication Date | 2023/01/03 |
| Type | |
| Peer Review | Peer reviewed |
| Title | Artificial cerebrospinal fluid restores aspirin‑inhibited physiological hemostasis through recovery of platelet aggregation function |
| Contribution Type | |
| Journal | Acta Neurochirurgica |
| Journal Type | Another Country |
| Publisher | Springer |
| Total page number | 8 |
| Responsible for | 本人担当区分：共同研究につき抽出不可能 |
| Author and coauthor | Ryosuke Suzuki · Yukinori Kozuma · Chisako Inoue · Kano Tanabe · Ippei Noboruo · Hohomi Arao · Tatsuya Kawaguchi · Nobuyuki Shimizu · Tetsuya Yamamoto |
| Details | Optimal hemostasis provides safety and reliability during neurosurgery which improves surgical outcomes. Previously, artificial cerebrospinal fluid (aCSF) and its component sodium bicarbonate were found to facilitate physiological hemostasis by amplifying platelet aggregation. This study aimed to verify whether aCSF amplifies platelet-dependent hemostasis in the presence of antiplatelet agents.
aCSF and sodium bicarbonate facilitate physiological hemostasis through the recovery of inhibited platelet aggregation even in the presence of ASA. The utilization of aCSF in the operative field may be advantageous for facilitating hemostasis in patients with impaired platelet function and contribute to improving outcomes of neurosurgery. |