ノボルオ　イッペイ   Ippei noboruo
  登尾　一平
   所属   熊本保健科学大学  保健科学部 医学検査学科
   職位   講師
言語種別 英語
発行・発表の年月 2023/01/03
形態種別 研究論文　
査読 査読あり
標題 Artificial cerebrospinal fluid restores aspirin‑inhibited physiological hemostasis through recovery of platelet aggregation function
執筆形態 共著
掲載誌名 Acta Neurochirurgica
掲載区分国外
出版社・発行元 Springer
総ページ数 8
担当範囲 本人担当区分：共同研究につき抽出不可能
著者・共著者 Ryosuke Suzuki · Yukinori Kozuma · Chisako Inoue · Kano Tanabe · Ippei Noboruo · Hohomi Arao · Tatsuya Kawaguchi · Nobuyuki Shimizu · Tetsuya Yamamoto
概要 Optimal hemostasis provides safety and reliability during neurosurgery which improves surgical outcomes. Previously, artificial cerebrospinal fluid (aCSF) and its component sodium bicarbonate were found to facilitate physiological hemostasis by amplifying platelet aggregation. This study aimed to verify whether aCSF amplifies platelet-dependent hemostasis in the presence of antiplatelet agents.
aCSF and sodium bicarbonate facilitate physiological hemostasis through the recovery of inhibited platelet aggregation even in the presence of ASA. The utilization of aCSF in the operative field may be advantageous for facilitating hemostasis in patients with impaired platelet function and contribute to improving outcomes of neurosurgery.