|
TAKASHI Tanaka
Department Kumamoto Health Science University Division of Physical Therapy, Faculty of Health Science Kumamoto Health Science University Graduate School Division of Health Sciences, Graduate School of Health Sciences Position Associate Professor |
|
| Language | English |
| Publication Date | 2023/07 |
| Type | |
| Peer Review | Peer reviewed |
| Title | ATF6β deficiency elicits anxiety-like behavior and hyperactivity under stress conditions |
| Contribution Type | |
| Journal | Neurochemical Research |
| Journal Type | Another Country |
| Volume, Issue, Page | 48(7),pp.2175-2186 |
| Authorship | Lead author |
| International coauthorship | International coauthorship |
| Author and coauthor | Tanaka T, Nguyen DT, Kwankaew N, Sumizono M, Shinoda R, Ishii H, Takarada-Iemata M, Hattori T, Oyadomari S, Kato N, Mori K, Hori O. |
| Details | Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER) stress-regulated transcription factor that induces expression of major molecular chaperones in the ER. This study suggests that ATF6β deficiency produces anxiety-like behavior and hyperactivity via a corticotropin-releasing hormone receptor 1-dependent mechanism. ATF6β could play a role in psychiatric conditions in the emotional centers of the brain. |
| DOI | 10.1007/s11064-023-03900-4 |