Motohiro Takeya
   Department   Kumamoto Health Science University  Department of Medical Technology, Faculty of Health Science
   Position   Professor
Research Period 2004~2007
Research Topic Application of CD204 (scavenger receptor) to histopathological diagnosis and production of new anti-macrophage antibodies
Research Type KAKENHI Research
Consignor Ministry of Education, Culture, Sports, Science and Technology
Research Program Type Grants-in-Aid for Scientific Research(基盤研究(B)),基盤研究(B)
KAKENHI Grant No. 16390108
Representative Person Motohiro TAKEYA
Collaborative Researcher 吉松 美佳, 寺崎 泰弘, Koichi KAIKITA, Naomi SAKASHITA
Details Scavenger receptors possess wide-ranged ligand-binding specificities and are considered to be one of the pattern recognition receptors that play important roles in host defence. Among such receptors, CD204 (Class A scavenger receptor Type I and II) and CD163 (hemoglobin scavenger receptor) are expressed exclusively on macrophages and considered to be a good marker for macrophages in histopathology. Using self-made antibodies, we have shown that CD204 and CD163 are positive for resident macrophages and a population of inflammatory macrophages in paraffin sections. In granulomatous diseases such as tuberculosis and sarcoidosis, infiltrated macropages surrounding the granulomas were positive for CD204 and CD163, however multinucleated giant cells were negative or only weakly labeled. Since CD204 and CD163 are induced in alternatively activated macrophages, these antibodies are considered to be valuable tools to label such macrophage subpopulation in hitopathological specimens.In animal models of acute myocardial infarction and high-dose oxygen-induced lung injury, CD204-deficient mice showed exacerbation of disease process in both models. In myocardial infarction model, CD204-deficien
Permalink URL