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Motohiro Takeya
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science Position Professor |
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| Research Period | 2008～2010 |
| Research Topic | ROLE OF SCAVENGER RECEPTORS IN MACROPHAGE ACTIVATION AND THEIR APPLICATION FOR DIAGNOSIS AND THERAPY |
| Research Type | KAKENHI Research |
| Consignor | Ministry of Education, Culture, Sports, Science and Technology |
| Research Program Type | Grants-in-Aid for Scientific Research(基盤研究(B)),基盤研究(B) |
| KAKENHI Grant No. | 20390113 |
| Representative Person | Motohiro TAKEYA |
| Collaborative Researcher | Naomi SAKASHITA, Yoshihiro KOMOHARA, Yukio FUJIWARA |
| Details | Using class A scavenger receptor (SR-A, CD204)-deficient macrophages, we disclosed that SR-A suppresses the macrophage activation by inhibiting the binding of LPS to TLR4 in a competitive manner. The result indicates SR-A plays a pivotal role in the regulation of the LPS-induced inflammatory response. Density of CD163-positive macrophages in tumors positively correlated with the malignant grade of glioma and epithelial ovarian cancer. It was found that M2 macrophages and tumor cells interact via STAT3. By screening natural compounds, corosolic acid was found to suppress M2 polarization of macrophages. This compound could be a potentially new tool for tumor prevention and therapy. |
| Permalink URL | https://kaken.nii.ac.jp/d/p/20390113.ja.html |