Motohiro Takeya
   Department   Kumamoto Health Science University  Department of Medical Technology, Faculty of Health Science
   Position   Professor
Research Period 2008~2010
Research Topic Functional analysis of the ACAT-1-positive late endosomes in cholesterol-rich macrophages
Research Type KAKENHI Research
Consignor Ministry of Education, Culture, Sports, Science and Technology
Research Program Type Grants-in-Aid for Scientific Research(基盤研究(C)),基盤研究(C)
KAKENHI Grant No. 20590384
Representative Person Naomi SAKASHITA
Collaborative Researcher Motohiro TAKEYA, Yoshihiro KOMOHARA, Yukio FUJIWARA
Details We functionally analyzed ACAT1-positive late endosomes (ACAT1-LE) which appears in cholesterol-rich macrophages. ACAT1-LE contributed effective cholesterol esterification, in addition, they showed impaired phagosomal maturation. Interestingly, such impairment partially correlated by pharmacological inhibition of cholesterol esterification.
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