Motohiro Takeya
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science Position Professor |
|
Research Period | 2008~2010 |
Research Topic | Functional analysis of the ACAT-1-positive late endosomes in cholesterol-rich macrophages |
Research Type | KAKENHI Research |
Consignor | Ministry of Education, Culture, Sports, Science and Technology |
Research Program Type | Grants-in-Aid for Scientific Research(基盤研究(C)),基盤研究(C) |
KAKENHI Grant No. | 20590384 |
Representative Person | Naomi SAKASHITA |
Collaborative Researcher | Motohiro TAKEYA, Yoshihiro KOMOHARA, Yukio FUJIWARA |
Details | We functionally analyzed ACAT1-positive late endosomes (ACAT1-LE) which appears in cholesterol-rich macrophages. ACAT1-LE contributed effective cholesterol esterification, in addition, they showed impaired phagosomal maturation. Interestingly, such impairment partially correlated by pharmacological inhibition of cholesterol esterification. |
Permalink URL | https://kaken.nii.ac.jp/d/p/20590384.ja.html |