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Motohiro Takeya
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science Position Professor |
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| Research Period | 2011～2013 |
| Research Topic | Development of new therapeutic strategies for regulating macrophage activation by natural compounds |
| Research Type | KAKENHI Research |
| Consignor | Ministry of Education, Culture, Sports, Science and Technology |
| Research Program Type | Grants-in-Aid for Scientific Research(挑戦的萌芽研究),挑戦的萌芽研究 |
| KAKENHI Grant No. | 23659204 |
| Representative Person | Motohiro TAKEYA |
| Collaborative Researcher | Naomi SAKASHITA, 菰原 義弘, Yukio FUJIWARA |
| Details | Macrophages are variously activated in disease environment. For example, M1-activated macrophages are involved in obesity and atherosclerosis, whereas M2-activated tumor-associated macrophages promote tumor progression. To develop new therapeutic strategies we identified several compounds that regulate M1- or M2-activation of macrophages by screening the library of natural compounds. Among them, colosolic acid and onionin A suppressed tumor progression by means of suppressing STAT3 activation. These two compounds significantly suppressed subcutaneous tumor development and lung metastasis in a murine sarcoma model. Through these results, application of colosolic acid and onionin A is considered a potential new anticancer therapy targeting macrophage activation. |
| Permalink URL | https://kaken.nii.ac.jp/d/p/23659204.ja.html |