Motohiro Takeya
   Department   Kumamoto Health Science University  Department of Medical Technology, Faculty of Health Science
   Position   Professor
Research Period 2011~2013
Research Topic Development of new therapeutic strategies for regulating macrophage activation by natural compounds
Research Type KAKENHI Research
Consignor Ministry of Education, Culture, Sports, Science and Technology
Research Program Type Grants-in-Aid for Scientific Research(挑戦的萌芽研究),挑戦的萌芽研究
KAKENHI Grant No. 23659204
Representative Person Motohiro TAKEYA
Collaborative Researcher Naomi SAKASHITA, 菰原 義弘, Yukio FUJIWARA
Details Macrophages are variously activated in disease environment. For example, M1-activated macrophages are involved in obesity and atherosclerosis, whereas M2-activated tumor-associated macrophages promote tumor progression. To develop new therapeutic strategies we identified several compounds that regulate M1- or M2-activation of macrophages by screening the library of natural compounds. Among them, colosolic acid and onionin A suppressed tumor progression by means of suppressing STAT3 activation. These two compounds significantly suppressed subcutaneous tumor development and lung metastasis in a murine sarcoma model. Through these results, application of colosolic acid and onionin A is considered a potential new anticancer therapy targeting macrophage activation.
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