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Motohiro Takeya
Department Kumamoto Health Science University Department of Medical Technology, Faculty of Health Science Position Professor |
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| Research Period | 2000～2002 |
| Research Topic | Role of scavenger receptors in atherogenesis and development of new therapeutic methods |
| Research Type | KAKENHI Research |
| Consignor | Ministry of Education, Culture, Sports, Science and Technology |
| Research Program Type | Grants-in-Aid for Scientific Research(基盤研究(B)),基盤研究(B) |
| KAKENHI Grant No. | 12557023 |
| Representative Person | Motohiro TAKEYA |
| Collaborative Researcher | Hiroshi SUZUKI, Naomi SAKASHITA, Yasuhiro TERASAKI, Koichi KAIKITA |
| Details | Scavenger receptors (SRs) are a family of cell surface glycoproteins able to bind modified LDLs such as acetyiated LDL and oxidized LDL. Currently, SR family molecules are classified into six groups, namely class A to class F. Class A SR type I and type II(SR-AI,II) was the first SR to be cloned. In our previous study, SR-A I,II deficiency induced 60 % reduction of atherosclerotic lesions in atherpgenic ApoE-deficient mice of crossbred strains. To exdude the influence of crossbreeding, a new study using inbred C57BL/6J mice has been performed in me present project After 7 months of high fat diet, 70% reduction of lesion size was observed inSR-A I,II deficient C57BL/6J mice. On the other hand, administration of BO-653, a new antioxidant, has induced 75% size reduction in normal C57BL/6J mice. This fact indicated that anti-oxidant therapy is similarly or more effective in reducing atherogenesis compared to SR-AI,II deficiency.To explore the effect of other types of SRs, we have studies the lesion development using a mouse strain that is deficient in a class E scavenger receptor, LOX-1 (lectin-like oxidized LDL receptor-1). So far, however, no significant difference in lesion size has |
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