Motohiro Takeya
   Department   Kumamoto Health Science University  Department of Medical Technology, Faculty of Health Science
   Position   Professor
Research Period 2001~2003
Research Topic IN VIVO EXPRESSION AND PATHOLOGICAL ROLES OF SCAVENGER RECEPTOR FAMILY MOLECULES
Research Type KAKENHI Research
Consignor Ministry of Education, Culture, Sports, Science and Technology
Research Program Type Grants-in-Aid for Scientific Research(基盤研究(B)),基盤研究(B)
KAKENHI Grant No. 13470052
Representative Person Motohiro TAKEYA
Collaborative Researcher Yasuhiro TERASAKI, Naomi SAKASHITA, Koichi KAIKITA
Details Scavenger receptors (SRs) are a family of cell surface glycoproteins able to bind modified LDLs such as acetylated LDL and oxidized LDL. Currently, SR family molecules are classified into six groups, namely class A to class F. To examine the in vivo distribution and the roles of human class A scavenger receptor Type I, II (SR-AI,II),a prototype of SRs, we have produced highly-specific monoclonal antibodies. Using these antibodies, SR-AI,II was found to be expressed constitutionally on most tissue macrophages such as Kupffer cells of the liver, alveolar macrophages, sinushsitiocytes of lymph nodes and splenic red pulp macrophages. In pathological conditions, infiltrated macrophages in inflammatory tissues including those composing various kinds of granulomas, microglial cells in Alzheimer's disease, and lipid-laden macrophages in atherosclerosis were positively labeled. SR-AI,II expression was also found in 10-15 % of monocyte-derived dendritic cells treated with GM-CSF and IL-4. These results indicate that SR-AI,II plays important roles both in innate and acquired immunities as well as atherogenesis. Through these observations, SR-AI,II has been assigned as a new CD molecule, CD20
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