ヒガシ　ヤスヒコ
  東　康彦
   所属   薬学部 薬学科
   職種   教授
言語種別 英語
発行・発表の年月 2007
形態種別 学術論文
査読 査読あり
標題 Simultaneous determination of four basic metabolites of butyrophenone-type agents in rat plasma by high-performance liquid chromatography with fluorescence detection after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole
執筆形態 共著
掲載誌名 J. Liq. Chromatogr. & Rel. Technol.
巻・号・頁 30(18),pp.2747-2754
著者・共著者 Yasuhiko Higashi, Masatoshi Sakata, and Youichi Fujii
概要 The basic metabolites of butyrophenone-type agents are sometimes more neurotoxic than the parent compounds. We have developed a high-performance liquid chromatographic method with fluorescence detection (HPLC－FL) to quantify the N-dealkylated basic metabolites, i.e., 1,3-dihydro-1-(1,2,3,6-tetrahydro-4-pyridinyl)-2H-benzimidazole-2-one, 1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, 4-(4-chlorophenyl)-4-hydroxypiperidine, and 4-(4-bromophenyl)-4-hydroxypiperidine, of droperidol, spiperone, haloperidol, and bromperidol, respectively, in rat plasma after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F).