ヒガシ　ヤスヒコ
  東　康彦
   所属   薬学部 薬学科
   職種   教授
言語種別 英語
発行・発表の年月 2010
形態種別 学術論文
査読 査読あり
標題 Determination of fluoxetine enantiomers in human serum and urine by isocratic HPLC and pre-column fluorescence derivatization with (R)-(+)-4-nitro-7-(2-chloroformylpyrrolidin-1-yl)-2,1,3-benzoxadiazole
執筆形態 共著
掲載誌名 J. Liq. Chromatogr. & Rel. Technol.
巻・号・頁 33(4),pp.481-490
著者・共著者 Yasuhiko Higashi, Ranzhi Gao, and Youichi Fujii
概要 Fluoxetine (FLX) is a highly selective serotonin reuptake inhibitor used as an antidepressant agent and administered as the racemate. In this study, we developed an isocratic HPLC method with fluorescence detection for the determination of FLX enantiomers ((R)-FLX and (S)-FLX) in human serum and urine, after pre-column derivatization with (R)-(+)-4-nitro-7-(2-chloroformylpyrrolidin-1-yl)-2,1,3-benzoxadiazole ((R)-(+)-NBD-Pro-COCl).