オガタ　トクタロウ
  尾形　篤太郎
   所属   薬学部 薬学科
   職種   講師
言語種別 英語
発行・発表の年月 2016/02
形態種別 学術論文
査読 査読あり
標題 Unusual, chemoselective etherification of 2-hydroxy-1,4-naphthoquinone derivatives utilizing alkoxymethyl chlorides: scope, mechanism and application to the synthesis of biologically active natural product (±)-lantalucratin C
執筆形態 共著
掲載誌名 Tetrahedron
掲載区分国外
出版社・発行元 Elsevier Ltd.
巻・号・頁 72(11),pp.1423-1432
著者・共著者 Ogata, Tokutaro; Yoshida, Tomoyo; Shimizu, Maki; Tanaka, Manami; Fukuhara, Chie; Ishii, Junko; Nishiuchi, Arisa; Inamoto, Kiyofumi; Kimachi, Tetsutaro
概要 A novel etherification of 2-hydroxy-1,4-naphthoquinone derivs. with alkoxyalkyl chlorides and hydride bases is described. Precise study of the conditions and substrate scope suggested that the reaction occurs specifically in the mol. having a 2-hydroxy-1,4-benzoquinone skeleton. A chemoselective O-methylation reaction was achieved to afford a synthetically important intermediate, which offered easy access to a natural product possessing anti-tumor activity.