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オヤマダ マサヒト
Oyamada Masahito
小山田 正人 所属 藤女子大学 人間生活学部 食物栄養学科 職種 特任教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2009/01 |
| 形態種別 | 研究論文（学術雑誌） |
| 査読 | 査読あり |
| 標題 | Roles of gap junctions in glucose transport from glucose transporter 1-positive to -negative cells in the lateral wall of the rat cochlea |
| 執筆形態 | 共著 |
| 掲載誌名 | HISTOCHEMISTRY AND CELL BIOLOGY |
| 掲載区分 | 国外 |
| 出版社・発行元 | SPRINGER |
| 巻・号・頁 | 131(1),pp.89-102 |
| 担当区分 | 責任著者 |
| 著者・共著者 | Toshihiro Suzuki,Tatsuya Matsunami,Yasuo Hisa,Kuniaki Takata,Tetsuro Takamatsu,Masahito Oyamada |
| 概要 | We hypothesized that gap junctions mediate intercellular glucose transport in the cochlea in cooperation with facilitative glucose transporter 1 (GLUT1). Immunohistochemistry showed that GLUT1 and the tight junction protein occludin were expressed in blood vessels, and GLUT1, the gap junction proteins connexin26 and connexin30, and occludin were also present in strial basal cells in the lateral wall of the rat cochlea. Gap junctions were found among not only these GLUT1-positive strial basal cells but also GLUT1-negative fibrocytes in the spiral ligaments and strial intermediate cells. Glucose imaging using 6-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-6-deoxyglucose (6-NBDG, MW 342) together with Evans Blue Albumin (EBA, MW 68,000) showed that 6-NBDG was rapidly distributed throughout the stria vascularis and spiral ligament, whereas EBA was localized only in the vessels. |
| DOI | 10.1007/s00418-008-0502-z |
| ISSN | 09486143 |
| PMID | 18787834 |
| PermalinkURL | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=65849302622&origin=inward |