ミツモト　ヤスヒデ   Yasuhide Mitsumoto
  光本　泰秀
   所属   薬学部 薬学科
   職種   教授
言語種別 英語
発行・発表の年月 2012/02
形態種別 学術論文
査読 査読あり
標題 Oral administration of coenzyme Q(10) reduces MPTP-induced loss of dopaminergic nerve terminals in the striatum in mice.
執筆形態 共著
掲載誌名 Neurological Sciences
出版社・発行元 Springer
巻・号・頁 33(1),pp.195-9
著者・共著者 Shota Kobayashi, Akiko Muroyama, Hiroaki Matsushima, Ikuo Yoshimura and Yasuhide Mitsumoto
概要 The neuroprotective effect of coenzyme Q(10) (CoQ(10)) has been reported in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. In this study, we investigated whether oral administration of CoQ(10) could protect the striatal dopaminergic (DAergic) nerve terminals against MPTP-induced toxicity in C57BL/6N mice using immunoisolation technique for DAergic synaptosomes. CoQ(10) significantly attenuated decrease in dopamine transporter as well as in synaptophysin and actin protein levels in DAergic synaptosomes from MPTP-treated mice. The effect of CoQ(10) was also observed in crude synaptosomes fraction, but not in homogenate. Our results indicate that the nerve terminals are a site for the action of CoQ(10) against the MPTP-induced DAergic neurodegeneration.
DOI 10.1007/s10072-011-0627-z