|
教員教育・研究情報 |
|
ミツモト ヤスヒデ
Yasuhide Mitsumoto
光本 泰秀 所属 薬学部 薬学科 職種 教授 |
|
| 言語種別 | 英語 |
| 発行・発表の年月 | 2009/01 |
| 形態種別 | 学術論文 |
| 査読 | 査読あり |
| 標題 | Enhanced susceptibility to MPTP neurotoxicity in magnesium-deficient C57BL/6N mice |
| 執筆形態 | 共著 |
| 掲載誌名 | Neuroscience Research |
| 出版社・発行元 | Elsevier Ireland Ltd and the Japan Neuroscience Society |
| 巻・号・頁 | 63(1),pp.72-75 |
| 著者・共著者 | Akiko Muroyamaa, Makiko Inakaa, Hiroaki Matsushimaa, Haruhiko Suginob, Yoshinori Marunakab and Yasuhide Mitsumoto |
| 概要 | We evaluated the effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6N mice fed a magnesium (Mg2+)-deficient diet. On the 3rd week, Mg2+-deficient mice displayed increased anxiety- and depression-like behavior. In the Mg2+-deficient mice, a low does (10 mg/kg) of MPTP treatment decreased dopamine (DA) and its metabolites contents in the striatum, but not in control mice. The same dose of MPTP did not influence these neurochemical markers in the mice fed Mg2+-deficient diet for 1 week which did not exhibit the altered emotional behavior. These results indicate that Mg2+-deficient mice with altered emotional behavior appear to increase the susceptibility to MPTP neurotoxicity in C57BL/6N mice. |
| ISSN | 0168-0102 |