ミツモト　ヤスヒデ   Yasuhide Mitsumoto
  光本　泰秀
   所属   薬学部 薬学科
   職種   教授
言語種別 英語
発行・発表の年月 2004/05
形態種別 学術論文
査読 査読あり
標題 Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan
執筆形態 共著
掲載誌名 Bioorg Med Chem Lett
掲載区分国外
巻・号・頁 17,pp.2621-2625
著者・共著者 Tomoyuki Esumi, Gouki Makado, Haifeng Zhai, Yasuhiro Shimizu, Yasuhide Mitsumoto, Yoshiyasu Fukuyama
概要 Honokiol, a biphenyl-type neolignan, which shows the remarkable neurotrophic effect in primary cultured rat cortical neurons, has been effectively synthesized in 21% yield over 14 steps starting from 5-bromosalicylic acid and p-hydroxybenzoic acid by utilizing Pd-catalyzed Suzuki-Miyaura coupling reaction as a key step. Additionally, the structure-activity relationship between neurite outgrowth-promoting activity and its O-methylated and/or its hydrogenated analogues was examined in the primary cultures of fetal rat cortical neurons, suggesting that 5-allyl and 4'-hydroxyl groups are essential for affecting the neurotrophic activity of honokiol.