ミツモト　ヤスヒデ   Yasuhide Mitsumoto
  光本　泰秀
   所属   薬学部 薬学科
   職種   教授
言語種別 英語
発行・発表の年月 2004/07
形態種別 学術論文
査読 査読あり
標題 Neurotrophic effects of talaumidin, a neolignan from Aristolochia arcuata, in primary cultured rat cortical neurons
執筆形態 共著
掲載誌名 Planta Med
掲載区分国外
巻・号・頁 70,pp.598-602
著者・共著者 Haifeng Zhai, Mika Nakatsukasa, Yasuhide Mitsumoto, Yoshiyasu Fukuyama
概要 Talaumidin, a tetrahydrofuran neolignan isolated from the root of Aristolochia arcuata, was shown to be an intriguing small molecule with neurotrophic activity in the primary culture of rat cortical neurons. Talaumidin can promote both dendrite-like and axon-like process outgrowth of cultured rat cortical neurons at the concentration range of 1-30 microm. Additionally, in the trophic withdrawal model, it can protect cell death caused by the deprivation of serum at the concentration range of 3-30 microm. These data suggest the potential of talaumidin to serve as a promising lead compound for treatment of neurodegenerative diseases.