ミツモト　ヤスヒデ   Yasuhide Mitsumoto
  光本　泰秀
   所属   薬学部 薬学科
   職種   教授
言語種別 英語
発行・発表の年月 2005/02
形態種別 学術論文
査読 査読あり
標題 Neuroprotective effects of 2,5-diaryl-3,4-dimethyltetrahydrofuran neolignans
執筆形態 共著
掲載誌名 Biol Pharm Bull
掲載区分国外
出版社・発行元 J-STAGE
巻・号・頁 28(2),pp.289-293
著者・共著者 Zhai H, Inoue T, Moriyama M, Esumi T, Mitsumoto Y, Fukuyama Y.
概要 We previously reported the neurotrophic effects of talaumidin (1) from Aristolochia arcuata MASTERS. In the present study, we compared the neurotrophic and neuroprotective effects of six other 2,5-diaryl-3,4-dimethyltetrahydrofuran neolignans isolated from the same plant, veraguensin (2), galgravin (3), aristolignin (4), nectandrin A (5), isonectandrin B (6), and nectandrin B (7), with compound 1 in primary cultured rat neurons. Compounds 3—7 promoted neuronal survival and neurite outgrowth, among which compounds 6 and 7 showed neurotrophic activity comparable with that of 1. Furthermore, compounds 1—7 protected hippocampal neurons against amyloid β peptide (Aβ25—35)-induced cytotoxicity, while compounds 1 and 4—7 protected against neuronal death from 1-methyl-4-phenylpyridinium ion (MPP+)-induced toxicity in cultured rat hippocampal neurons.